Costeira, Maria JoséOliveira, PedroCorreia Santos, NadineAres, SusanaSáenz-Rico de Santiago, María BelénMorreale de Escobar, GabriellaAlmeida Palha, Joana2024-02-072024-02-072011Costeira, M.J., Oliveira, P., Santos, N.C., Ares, S., Saenz-Rico, B., De Escobar, G.M.and Palha, J.A. (2011). The Journal of Pediatrics, 159(3), 447-453. https://doi.org/10.1016/j.jpeds.2011.02.0340022-347610.1016/j.jpeds.2011.02.034https://hdl.handle.net/20.500.14352/100132Estudio realizado por un equipo de investigación interdisciplinar dada la naturaleza de la población y el objeto de estudio. Supported by the Portuguese Science Foundation (FCT)- FEDER (POCTI_PSI_60948_2004) and Integrated Actions for exchange of scientists ‘‘Portugal-Spain E-84/ 2006’’ (by Fundacao para a Ciencia e Tecnologia, Portugal and by Ministerio de Educacion y Ciencia, Spain).Objectives To assess the psychomotor development of the progeny of women from a moderately iodine deficient area for whom thyroid function during pregnancy was measured. Study design The development of 86 children was assessed by the Bayley Scale of Infant Development at 12, 18,and 24 months. Results Maternal serum free thyroxine (FT4) levels in the first trimester of pregnancy were the major determinant ofpsychomotor development at 18 and 24 months. Children born from mothers with FT4 levels <25th percentile (<10pg/mL) had an OR of 2.1 for mild-to-severe delay. Furthermore, alterations in behavior were already observed at 12 months and were related to subsequent changes in development. Neonatal thyroid status did not influence development. Conclusions This study highlights the need to implement active measures of iodine supplementation pericon ceptionally and during pregnancy and lactation because the negative effects on development and behavior mightbe prevented through preemptive actionengjournal article1097-6833https://doi.org/10.1016/j.jpeds.2011.02.03421492867https://produccioncientifica.ucm.es/documentos/5df8a9ec2999525886b7144dhttps://scholar.google.com/scholar_lookup?title=Psychomotor+development+of+children+from+an+iodine-deficient+region&author=Costeira%2C+M.J.&author=Oliveira%2C+P.&author=Santos%2C+N.C.&author=Ares%2C+S.&author=Saenz-Rico%2C+B.&author=De+Escobar%2C+G.M.&author=Palha%2C+J.A.&publication_year=2011&journal=Journal+of+Pediatrics&volume=159&issue=3&pages=447-453&doi=10.1016/J.JPEDS.2011.02.034&pmid=21492867&issn=0022-3476&hl=esrestricted access37.012612.65-053.2616-053.2Psychomotor developmentChildrenIodineCiencias BiomédicasCiencias SocialesMétodos de investigación en educaciónPediatría32 Ciencias Médicas58 Pedagogía