Fernández Lamo, IvánGómez Domínguez, DanielSánchez-Aguilera López, AlbertoOliva, AzaharaMorales, Aixa VictoriaValero, ManuelCid, ElenaBerenyi, AntalMenéndez de la Prida, Liset2024-11-192024-11-192019-02-12Ivan Fernandez-Lamo, Daniel Gomez-Dominguez, Alberto Sanchez-Aguilera, Azahara Oliva, Aixa Victoria Morales, Manuel Valero, Elena Cid, Antal Berenyi, Liset Menendez de la Prida, Proximodistal Organization of the CA2 Hippocampal Area, Cell Reports, Volume 26, Issue 7, 2019, Pages 1734-1746.e6, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2019.01.060.10.1016/j.celrep.2019.01.060https://hdl.handle.net/20.500.14352/110763The proximodistal axis is considered a major organizational principle of the hippocampus. At the interface between the hippocampus and other brain structures, CA2 apparently breaks this rule. The region is involved in social, temporal, and contextual memory function, but mechanisms remain elusive. Here,werevealcell-typeheterogeneityandacharacteristic expression gradient of the transcription factor Sox5 within CA2 in the rat. Using intracellular andextracellular recordings followedby neurochemical identification of single cells, we find marked proximodistal trends of synaptic activity, subthreshold membrane potentials, and phase-locked firing coupled to theta and gamma oscillations. Phaseshifting membrane potentials and opposite proximodistal correlations with theta sinks and sources at different layers support influences from different current generators. CA2 oscillatory activity and place coding of rats running in a linear maze reflect proximodistal state-dependent trends. We suggest that the structure and function of CA2 are distributed along the proximodistal hippocampal axis.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article2211-1247https://doi.org/10.1016/j.celrep.2019.01.060https://www.sciencedirect.com/science/article/pii/S2211124719300890open access612.8cell typethetagammaPCP4Sox5Neurociencias (Medicina)2490.01 Neurofisiología