Dominguez Centeno, IsabelJurado Barba, RosaSion, Ana Mª AlexandraMartínez Maldonado, AndrésCastillo Parra, GabrielaLópez Muñoz, FranciscoRubio Valladolid, GabrielMartínez Gras, María Isabel2026-03-052026-03-052018-11I Domínguez-Centeno, R Jurado-Barba, A Sion, A Martinez-Maldonado, G Castillo-Parra, F López-Muñoz, G Rubio, I Martinez-Gras. P3 Component as a Potential Endophenotype for Control Inhibition in Offspring of Alcoholics, Alcohol and Alcoholism, Volume 53, Issue 6, November 2018, Pages 699–706, https://doi.org/10.1093/alcalc/agy05110.1093/alcalc/agy051https://hdl.handle.net/20.500.14352/133801Aims: To assess inhibitory processes and the ongoing event-related potential (ERP) activity of offspring of alcoholics (OA) during a Go/No-Go task, with the purpose of characterizing possible psychophysiological endophenotypes for alcohol-dependent vulnerability. Methods: ERP measurements were obtained by electroencephalogram (EEG) recordings of 65 participants divided into two groups: one group of 30 subjects with positive family history of alcoholism and a control group of 35 subjects with negative family history of alcoholism. They performed a Go/No-Go task, where each individual was required to classify visual stimuli by colour (Go) and inhibit their response to a No-Go signal. Results: OA have higher P3 amplitudes during the Go condition in all of the regions analysed and higher No-Go P3 amplitudes than control subjects in the frontal region. Unlike controls, OA have no differences between the P3 amplitudes across conditions. Conclusions: The absence of differences between the P3 Go and No-Go observed in the OA group can be interpreted as a possible alteration related with inhibition, in a way that they may need to recruit similar resources for inhibitory and classificational processes for both conditions. Therefore, the P3 component may be considered as a useful endophenotype and a vulnerability marker to develop addictive behaviour.engjournal article1464-3502https://doi.org/10.1093/alcalc/agy05130020398open accessElectroencephalographyInhibitionGo/No-Go taskInhibitionAlcoholOffspringEndophenotypeEndophenotypeNeuropsicologíaPsicología fisiológica61 Psicología