Martínez Rodríguez, NataliaBarona Dorado, CristinaMartín-Arés, MaríaCortés Bretón Brinkmann, JorgeMartínez González, José María2025-12-162025-12-162012-03Martínez-Rodríguez N, Barona-Dorado C, Martín-Arés M, Cortés-Bretón-Brinkman J, Martínez-González JM. Evaluation of the anaesthetic properties and tolerance of 1:100,000 articaine versus 1:100,000 lidocaine. A comparative study in surgery of the lower third molar. Med Oral Patol Oral Cir Bucal. 2012 Mar 1;17(2):e345-51. doi: 10.4317/medoral.17414.1698-444710.4317/medoral.17414https://hdl.handle.net/20.500.14352/129125Objectives: To evaluate the anaesthetic properties and tolerance of articaine versus lidocaine at equal vasoconstrictor concentration. Study design: A total of 96 male and female patients who underwent surgical treatment of the lower third molar participated. Patients were randomly assigned to articaine hydrochloride with epinephrine 1:100,000 and lidocaine hydrochloride with epinephrine 1:100,000. The variables analysed were latency period, duration of anaesthetic effect, tolerance and adverse reactions. Results: Both the latency period and the duration of anaesthetic effect were greater for articaine, although the differences were not statistically significant. Latency: mean difference of 2.70 ± 2.12 minutes (95%CI of -1.51 minutes - 6.92 minutes). Duration: mean difference of -33 minutes 5 seconds ± 31 minutes (95% CI -1 hour 35 minutes - 29 minutes). There were 4 adverse events that did not require the patients to be withdrawn from the study. Conclusions: The anaesthetics in this study have very similar properties for use in surgery and have demonstrated a good safety and tolerability profile.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1698-6946https://doi.org/10.4317/medoral.1741422143691https://pubmed.ncbi.nlm.nih.gov/22143691/open access615.211:616.314-089ArticaineLidocaineVasoconstrictorAdverse reactionsCiencias BiomédicasOdontología (Odontología)MedicamentosCirugía bucofacial32 Ciencias Médicas3201 Ciencias Clínicas3209.03 Evaluación de Medicamentos3213 Cirugía3213.13 Ortodoncia-Estomatología