Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis

Hernandez-Rocamora, V.M.Maestro García-Donas, María Beatrizde Waal, B.Morales, M.Garcia, P.Meijer, E. W.Sanz, J.M.2024-01-162024-01-162009-01-131433-785110.1002/anie.200803664https://hdl.handle.net/20.500.14352/93420Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrationsengMultivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysisjournal article1521-3773https://onlinelibrary.wiley.com/doi/10.1002/anie.200803664restricted access577.1Bioquímica (Química)2403 Bioquímica