Gómez, NestorWigdorovitz, AndresCastañón, SoniaGil Dones, FélixOrdá, RicardoBorca, ManuelEscribano, José2024-01-242024-01-242000Gómez, N., Wigdorovitz, A., Castañón, S. et al. Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus. Arch. Virol. 145, 1725–1732 (2000). https://doi.org/10.1007/s0070500700870304-860810.1007/s007050070087https://hdl.handle.net/20.500.14352/94970Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV.engjournal article1432-8798https://doi.org/10.1007/s007050070087open access581.15577.112Gastroenteritis coronavirusSpikeproteinBotánica (Biología)Genética2417 Biología Vegetal (Botánica)2409.92 Genética Molecular de Plantas