Garutti Martínez, IgnacioCruz, PatriciaOlmedilla, LuisBarrio, José MaríaCruz, AlbertoFernández, CarmenPérez Peña, José María2024-01-312024-01-312003Garutti I, Cruz P, Olmedilla L, Barrio JM, Cruz A, Fernandez C, Perez-Peña JM. Effects of thoracic epidural meperidine on arterial oxygenation during one-lung ventilation in thoracic surgery. J Cardiothorac Vasc Anesth. 2003 Jun;17(3):302-5. doi: 10.1016/s1053-0770(03)00056-91532-842210.1016/s1053-0770(03)00056-9https://hdl.handle.net/20.500.14352/97162Objective: To compare the effects that the use of general intravenous anesthesia (propofol-fentanyl) (GA) or general anesthesia combined with thoracic epidural anesthesia with meperidine (TEA-M) may have on arterial oxygenation during one-lung ventilation (OLV). Design: Prospective. Setting: Tertiary care hospital. Participants: Seventy-two patients undergoing OLV for thoracic surgery. Interventions: Patients were prospectively randomized into two groups: GA (n = 37) fentanyl, propofol, rocuronium anesthesia was used; and group TEA-M (n = 35) were anesthetized with propofol, rocuronium and thoracic epidural meperidine (2 mg/kg in 10-12 mL) administered before anesthetic induction. A double-lumen endotracheal tube was inserted, and mechanical ventilation with 100% oxygen was used during study. Mean arterial pressure, heart rate and arterial and venous blood gases were recorded with the patients in the lateral decubitus position in three phases: during two-lung ventilation (TLV), 15 and 30 minutes after beginning OLV (OLV + 15 and OLV + 30 respectively). The authors measured arterial and venous central oxygen tension, arterial and venous central oxygen saturation, arterial and venous central oxygen content and venous admixture percentage (Qs/Qt%). Measurements and main results: There were no statistical differences between the two groups for PaO(2) during OLV + 15 (GA = 165 mmHg, TEA-M = 153 mmHg) and OLV + 30 (GA = 176 mmHg, TEA-M = 158 mmHg); and with values for Qs/Qt%. Conclusions: It is concluded that GA combined with TEA-M (2 mg/kg) do not affect arterial oxygenation during OLV in thoracic surgery.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1016/S1053-0770(03)00056-9https://pubmed.ncbi.nlm.nih.gov/12827575/restricted access616.33/.38-089Ciencias Biomédicas32 Ciencias Médicas