Benchekroun, MohamedRomero Hernández, AlejandroEgea, JavierLeón Martínez, RafaelMichalska Dziama, PatrycjaBuendía, IzaskunJimeno, María LuisaJun, DanielJanockova, JanaSepsova, VendulaSoukup, OndrejBautista-Aguilera, Oscar M.Refouvelet, BernardOuari, OlivierMarco Contelles, José LuisIsmaili, Lhassane2024-01-312024-01-312016-10-1310.1021/acs.jmedchem.6b01178https://hdl.handle.net/20.500.14352/97148Novel multifunctional tacrines for Alzheimer’s disease were obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, according to the antioxidant additive approach in order to modulate the oxidative stress as therapeutic strategy. Compound 5c has been identified as a promising permeable agent showing excellent antioxidant properties, strong cholinesterase inhibitory activity, less hepatotoxicity than tacrine, and the best neuroprotective capacity, being able to significantly activate the Nrf2 transcriptional pathway.engjournal articlehttps://doi.org/10.1021/acs.jmedchem.6b01178restricted accessMultitarget ligandNrf2 pathwayAlzheimer´s diseaseDrug discoveryCiencias Biomédicas23 Química