Wang, HanfeiWang, BoyuZhang, JieyingTong, HaibinAres Lombán, IrmaMartínez Caballero, MartaLópez Torres, BernardoMartínez Larrañaga, María RosaPan, YuanhuZhang, JinjunAnadón Navarro, Arturo RamónWang, XuMartínez Caballero, María Aranzazu2026-03-182026-03-182026Wang, H., Wang, B., Zhang, J., Tong, H., Ares, I., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., Pan, Y., Zhang, J., Anadón, A., Wang, X., & Martínez, M. A. (2026). Concurrent management of gout and type 2 diabetes mellitus: combined therapy insights. Diabetes research and clinical practice, 234, 113169. https://doi.org/10.1016/j.diabres.2026.1131690168-822710.1016/j.diabres.2026.113169https://hdl.handle.net/20.500.14352/134112Credit authorship contribution statement Hanfei Wang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Boyu Wang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Jieying Zhang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Haibin Tong: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Irma Ares: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Marta Martínez: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Bernardo Lopez-Torres: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. María-Rosa Martínez-Larrañaga: Writing – review & editing, Investigation, Formal analysis, Data curation, Conceptualization. Yuanhu Pan: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Jinjun Zhang: Writing – review & editing, Writing – original draft, Visualization, Conceptualization. Arturo Anadón: Writing – review & editing, Supervision, Resources, Project administration. Xu Wang: Writing – review & editing, Supervision, Resources, Project administration. María-Aránzazu Martínez: Writing – review & editing, Supervision, Resources, Project administrationGout and type 2 diabetes mellitus (T2DM) are prevalent metabolic disorders with a significant bidirectional association. The review article focuses on the interplay between serum uric acid and glucose/lipid metabolism, innate immunity, inflammation, and gut microbiota, proposing simultaneous treatment strategies. Gout, caused by monosodium urate crystal deposition due to hyperuricaemia, and T2DM, induced by high-fat, high-sugar diets disrupting metabolic balance, share common pathological mechanisms. Elevated uric acid levels contribute to lipid and glucose metabolic disorders, activate inflammatory pathways like the nucleotide-binding oligomerization domain-like receptor 3 inflammasome, and trigger innate immune responses. The gut microbiota also plays a significant role in both metabolic diseases, with dysbiosis affecting uric acid excretion and insulin resistance. This review article highlights promising therapeutic approaches, including the use of sodium-glucose cotransporter-2 inhibitors which reduce serum uric acid and lowers gout risk alongside glycaemic control. Additionally, targeting inflammatory pathways such as interleukin-1β offers potential benefits for both conditions. Combined pharmacological therapies, dietary adjustments, and gut microbiota interventions present new directions for simultaneous management. This review article provides a comprehensive analysis of the links between gout and T2DM, offering novel insights for clinical practice and future researchengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1872-8227https://doi.org/10.1016/j.diabres.2026.11316941713504https://pubmed.ncbi.nlm.nih.gov/41713504/open access636.09:615GoutGut microbiotaHyperuricemiaInflammationType 2 diabetes mellitusFarmacología veterinaria3109.08 Farmacología