Pérez Liva, MailynViel, ThomasYoganathan, ThulacigaGarofalakis, AnikitosSourdon, JoevinFacchin, CaterinaTanter, MickaelProvost, JeanTavitian, Bertrand2026-01-282026-01-282018-09-21Perez-Liva, Mailyn, et al. «Performance evaluation of the PET component of a hybrid PET/CT-ultrafast ultrasound imaging instrument». Physics in Medicine & Biology, vol. 63, n.o 19, septiembre de 2018, p. 19NT01. DOI.org (Crossref), https://doi.org/10.1088/1361-6560/aad946.0031-915510.1088/1361-6560/aad946https://hdl.handle.net/20.500.14352/131210© 2018 Institute of Physics and Engineering in MedicineThis study was supported by France Life Imaging grant ANR-11-INBS-0006, by the Plan Cancer Physicancer (grant C16025KS) and by LABEX WIFI (Laboratory of Excellence ANR-10-LABX-24) within the French programme ‘Investments for the Future’ under reference ANR-10-IDEX-0001-02 PSL. Author MPL would like to acknowledge the support of the Plan Cancer Physicancer programme BIMUPET (C16025KS). In vivo imaging was performed at the Life Imaging Facility of Paris Descartes University (Plateforme Imageries du Vivant), supported by France Life Imaging (grant ANR-11-INBS-0006) and Infrastructures Biologie-Santé. The project also received the support of the Institut National de la Santé et de la Recherche Médicale (Inserm) Technology Research Accelerator in Biomedical Ultrasound.We recently introduced a hybrid imaging instrument, PETRUS, based on a combination of positron emission tomography (PET) for molecular imaging, x-ray computed tomography (CT) for anatomical imaging, co-registration and attenuation correction, and ultrafast ultrasound imaging (UUI) for motion-correction, hemodynamic and biomechanical imaging. In order to ensure a precise co-registration of simultaneous PET-UUI acquisitions, ultrasound probes attached to an ultrafast ultrasound scanner are operated in the field of view (FOV) of a small animal PET/CT scanner using a remote-controlled micro-positioner. Here we explore the effect of the presence of ultrasound probes on PET image quality. We compare the performance of PET and image quality with and without the presence of probes in the PET field of view, both in vitro following the NEMA-NU-4-2008 standard protocol, and in vivo in small animals. Overall, deviations in the quality of images acquired with and without the ultrasound probes were under 10% and under 7% for the NEMA protocol and in vivo tests, respectively. Our results demonstrate the capability of the PETRUS device to acquire multimodal images in vivo without significant degradation of image quality.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1361-6560https://doi.org/10.1088/1361-6560/aad946https://iopscience.iop.org/article/10.1088/1361-6560/aad946open access53NEMA ProtocolHybrid Imaging SystemsUltrafast Ultrasound ImagingPET ImagingUltrasound Probe Inside a PET GantryFísica (Física)22 Física