Menéndez Ramos, José CarlosRuiz Serrano, MiriamLópez-Alvarado Gutiérrez, María Pilar2025-12-182025-12-182023Ruiz-Serrano M, López-Alvarado P, Menéndez JC. A New Method for the Introduction of an Acylsulfonamide Moiety Applied to a 3-Substituted Functionalized Indole Framework ­Related to the Welwitindolinone Alkaloids. Synlett 2023;34:1920–4. https://doi.org/10.1055/a-2102-69270936-521410.1055/a-2102-6927https://hdl.handle.net/20.500.14352/129329The one-pot reaction between an α-formylcyclohexanone derivative and tosyl azide in the presence of rhodium trifluoroacetate dimer afforded an acylsulfonamide derivative. This transformation is proposed to arise from a domino mechanism involving the in situ generation, through the Regitz method, of an α-diazoketone, followed by its transformation into a rhodium carbenoid and its combination with N-tosylformamide, generated as a side product of the first step of the mechanism. Overall, this transformation leads to the generation of a C–N bond between the formyl carbon and the azide nitrogen adjacent to the sulfonyl group.engjournal article1437-2096https://doi.org/10.1055/a-2102-6927restricted access547IndolesMichael additionDiazo compoundsRhodium catalysisCarbenoidsDomino reactionQuímica orgánica (Química)2306 Química Orgánica