Echeverría, OlatzAlou Cervera, LuisSevillano Fernández, DavidGonzález Hidalgo, NataliaGómez-Lus Centelles, María LuisaAguilar, LorenzoPrieto Prieto, José2024-07-292024-07-292007-06Echeverria O, Alou L, Sevillano D, Gonzalez N, Gomez-Lus ML, Aguilar L, Prieto J. Pharmacodynamics of simulated total versus free-drug serum concentrations of a low versus a high protein bound third-generation oral cephalosporin (Cefpodoxime versus cefditoren) against Streptococcus pneumoniae. J Chemother. 2007 Jun;19(3):288-94.1120-009X10.1179/joc.2007.19.3.288https://hdl.handle.net/20.500.14352/107167Pharmacodynamic parameters and bactericidal activity against Streptococcus pneumoniae were investigated by simulating total and free serum concentrations of cefpodoxime versus cefditoren. Total drug T>MIC against the penicillin-intermediate (PISP) and resistant (PRSP) strains were 70.6% and 42.9% for cefpodoxime, and 89.6% and 62.5% for cefditoren, respectively. Comparing activity of free versus total cefpodoxime, there were reductions of 8.5% and 19.1% in T>MIC, related to bactericidal activity reductions from approximately 4.5 to 3 log10, and from 3 to 2.5 log10 against PISP and PRSP, respectively, at 10-12h. For cefditoren, reductions of 45.4% and 100% in T>MIC, were related to bactericidal activity reductions from approximately 5.5 to 2-2.5 log10 and from approximately 2.5 to 1.5 log10 against PISP and PRSP, respectively, at 10-12h. Higher differences in activity were found against the less resistant strains when comparing total versus free-drug profile.engjournal article1973-9478https://doi.org/10.1179/joc.2007.19.3.288https://www.tandfonline.com/doi/abs/10.1179/joc.2007.19.3.288restricted access611.02Bactericidal activitypharmacodynamic simulationprotein bindingcefpodoximecefditorenMicrobiología médica2414 Microbiología