Garrido Novelle, MartaNaranjo Martínez, BeatrizLópez Cánovas, Juan LuisDíaz Ruíz, Alberto2024-12-112024-12-112025-01Novelle, M. G., Naranjo-Martínez, B., López-Cánovas, J. L., & Díaz-Ruiz, A. (2025). Fecal microbiota transplantation, a tool to transfer healthy longevity. Ageing Research Reviews, 103, 102585. https://doi.org/10.1016/j.arr.2024.1025851568-163710.1016/j.arr.2024.102585https://hdl.handle.net/20.500.14352/112472This work was supported by the following grants: i) RETOS Projects Program PID2019-106893RA-I00 (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033; ii) Ramon y Cajal Award RYC2021-033751-I (grant to A.D.R), funded by MICIU/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR; iii) CIVP21A7025 (grant to A.D.R), funded by Ramón Areces Foundation; iv) Talento Grant (2018-T1/BMD-11966; grant to A.D.R), funded by Comunidad de Madrid; and v) CIBERobn, an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain, which is supported by FEDER funds. Figure 1 was designed by Freepik. Some Icons on Figures 2-4 were modified from BioRender.com.The complex gut microbiome influences host aging and plays an important role in the manifestation of age-related diseases. Restoring a healthy gut microbiome via Fecal Microbiota Transplantation (FMT) is receiving extensive consideration to therapeutically transfer healthy longevity. Herein, we comprehensively review the benefits of gut microbial rejuvenation - via FMT - to promote healthy aging, with few studies documenting life length properties. This review explores how preconditioning donors via standard - lifestyle and pharmacological - antiaging interventions reshape gut microbiome, with the resulting benefits being also FMT-transferable. Finally, we expose the current clinical uses of FMT in the context of aging therapy and address FMT challenges - regulatory landscape, protocol standardization, and health risks - that require refinement to effectively utilize microbiome interventions in the elderly.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1872-9649https://doi.org/10.1016/j.arr.2024.102585open access616.99Fecal microbiota transplantationAgingLongevityGut-microbiomeFMT-concernsCiencias BiomédicasGeriatría32 Ciencias Médicas3201.07 Geriatría