Sánchez Morales, LidiaBarroso Arévalo, SandraBarasona García-Arévalo, José ÁngelDomínguez Rodríguez, Lucas JoséSánchez-Vizcaíno Rodríguez, José Manuel2024-08-202024-08-202023Barroso-Arévalo, S., Sánchez-Morales, L., Barasona, J. A., Domínguez, L., & Sánchez-Vizcaíno, J. M. (2023). SARS-CoV-2 Seroprevalence Studies in Pets, Spain. Emerging Infectious Diseases, 29(6), 1136-1142. https://doi.org/10.3201/eid2906.2217371080-604010.3201/eid2906.221737https://hdl.handle.net/20.500.14352/107523Author contributions: conceptualization: S.B.-A., L.D., J.M.S.-V.; data curation: S.B.-A., L.S.-M., J.A.B.; formal analysis: S.B.-A., L.S.-M., J.A.B.; funding acquisition: J.M.S.-V., L.D.; laboratory analyses: S.B.-A., L.S.-M.; methodology: S.B.-A., L.S.-M., J.A.B., J.M.S.-V.; project administration: J.M.S.-V.; resources: L.D., J.M.S.-V.; software: S.B.-A., L.S.-M., J.A.B.; supervision: L.D., J.M.S.-V.; validation: S.B.-A., L.S.-M., J.A.B., J.M.S.-V.; visualization: S.B.-A., L.S.-M., J.A.B.; original draft preparation: S.B.-A., L.S.-M., J.A.B.; manuscript review and editing: S.B.-A., L.S.-M., J.A.B., L.D., J.M.S.-V.SARS-CoV-2 can infect domestic animals such as cats and dogs. The zoonotic origin of the disease requires surveillance on animals. Seroprevalence studies are useful tools for detecting previous exposure because the short period of virus shedding in animals makes detection of the virus difficult. We report on an extensive serosurvey on pets in Spain that covered 23 months. We included animals with exposure to SARS-CoV-2-infected persons, random animals, and stray animals in the study. We also evaluated epidemiologic variables such as human accumulated incidence and spatial location. We detected neutralizing antibodies in 3.59% of animals and showed a correlation between COVID-19 incidence in humans and positivity to antibody detection in pets. This study shows that more pets were infected with SARS-CoV-2 than in previous reports based on molecular research, and the findings highlight the need to establish preventive measures to avoid reverse zoonosis events.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3201/eid2906.22173737069624https://wwwnc.cdc.gov/eid/article/29/6/22-1737_articleopen access636.09COVID-19SARS-CoV-2Spainepidemiologypetsrespiratory infectionsseroprevalencesevere acute respiratory syndrome coronavirus 2viruseszoonosesVeterinaria3109 Ciencias Veterinarias