Miras Portugal, María TeresaOrtega De La O, FelipeGómez Villafuertes, María RosaGualix Sánchez, Francisco JavierPérez Sen, RaquelGarcía Delicado, Esmerilda2025-11-282025-11-282021Miras-Portugal, M. T., Ortega, F., Gómez-Villafuertes, R., Gualix, J., Pérez-Sen, R., & Delicado, E. G. (2021). P2X7 receptors in the central nervous system. Biochemical pharmacology, 187, 114472. https://doi.org/10.1016/j.bcp.2021.1144720006-295210.1016/j.bcp.2021.114472https://hdl.handle.net/20.500.14352/127367Received 30 November 2020; Received in revised form 5 February 2021; Accepted 8 February 2021. Available online 13 February 2021.For the past three decades, our laboratory has conducted pioneering research to elucidate the complexity of purinergic signaling in the CNS, alone and in collaboration with other groups, inspired by the ground-breaking efforts of Geoffrey Burnstock. This review summarizes our contribution to understand the nucleotide receptor signaling in the CNS with a special focus on the P2X7 receptor.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1873-2968https://doi.org/10.1016/j.bcp.2021.11447233587917https://pubmed.ncbi.nlm.nih.gov/33587917/restricted access61Calcium signalingNeuroprotectionNeurotransmissionNucleotide receptorP2X7 receptorNeurociencias (Biológicas)2490 Neurociencias