Burgos Blasco, BárbaraGüemes Villahoz, NoemiVidal Villegas, BeatrizMartínez De La Casa Fernández-Borrella, José MaríaDonate López, JuanMartín Sánchez, Francisco JavierGonzález Armengol, Juan JorgePorta Etessam, Mariano JesúsRodríguez Martin, José LuisGarcía Feijoo, Julián2023-06-172023-06-172021-03-15Burgos Blasco, B., Güemes Villahoz, N, Vidal Vilegas, B. et al. «Optic Nerve and Macular Optical Coherence Tomography in Recovered COVID-19 Patients». European Journal of Ophthalmology, vol. 32, n.o 1, enero de 2022, pp. 628-36. DOI.org (Crossref), https://doi.org/10.1177/11206721211001019.1120-672110.1177/11206721211001019https://hdl.handle.net/20.500.14352/8021Purpose: To investigate the peripapillary retinal nerve fiber layer thickness (RNFLT), macular RNFLT, ganglion cell layer (GCL), and inner plexiform layer (IPL) thickness in recovered COVID-19 patients compared to controls. Methods: Patients previously diagnosed with COVID-19 were included, while healthy patients formed the historic control group. All patients underwent an ophthalmological examination, including macular and optic nerve optical coherence tomography. In the case group, socio-demographic data, medical history, and neurological symptoms were collected. Results: One hundred sixty patients were included; 90 recovered COVID-19 patients and 70 controls. COVID-19 patients presented increases in global RNFLT (mean difference 4.3; CI95% 0.8 to 7.7), nasal superior (mean difference 6.9; CI95% 0.4 to 13.4), and nasal inferior (mean difference 10.2; CI95% 2.4 to 18.1) sectors of peripapillary RNFLT. Macular RNFL showed decreases in COVID-19 patients in volume (mean difference −0.05; CI95% −0.08 to −0.02), superior inner (mean difference −1.4; CI95% −2.5 to −0.4), nasal inner (mean difference −1.1; CI95% −1.8 to −0.3), and nasal outer (mean difference −4.7; CI95% −7.0 to −2.4) quadrants. COVID-19 patients presented increased GCL thickness in volume (mean difference 0.04; CI95% 0.01 to 0.07), superior outer (mean difference 2.1; CI95% 0.8 to 3.3), nasal outer (mean difference 2.5; CI95% 1.1 to 4.0), and inferior outer (mean difference1.2; CI95% 0.1 to 2.4) quadrants. COVID-19 patients with anosmia and ageusia presented an increase in peripapillary RNFLT and macular GCL compared to patients without these symptoms. Conclusions: SARS-CoV-2 may affect the optic nerve and cause changes in the retinal layers once the infection has resolved.engjournal article1724-6016https://doi.org/10.1177/11206721211001019https://journals.sagepub.com/doi/full/10.1177/11206721211001019open access616.98:578.834617.731-071.3617.736-071.3COVIDCoronavirusOptical coherence tomographyOptic nerveEnfermedades infecciosasOftalmologíaAnatomía ocular3205.05 Enfermedades Infecciosas3201.09 Oftalmología