Mayol Hornero, BeatrizGarcía-Díez, EstherHoppe, AlexanderEspejo, LucíaMuñoz, MirandaGonzález Barrios, Marta MaríaVillalonga, AnabelMoreno, TeresaSánchez, AlfredoVilela García, DianaMartínez Quiles, NarcisaMartínez Ruiz, María PalomaVillalonga Santana, Reynaldo2025-09-162025-09-162025Nanoscale, 2025, 17, 8183–819110.1039/d4nr03740ehttps://hdl.handle.net/20.500.14352/123997A masking/toposelective modification approach was employed to prepare a new organic–inorganic Janus nanomaterial by attaching ethylenediamine core polyamidoamine G-4.5 dendrimers to a defined face of mesoporous silica nanoparticles. The anisotropic colloid was then sequentially functionalized on the mesoporous face with (3-isocyanatopropyl)triethoxysilane, 1-(4-aminophenyl)-2-phenylethane-1,2- dione and β-cyclodextrin to assemble a novel H2O2-sensitive gating mechanism. The Janus nanomachine was finally constructed by immobilizing glucose oxidase on the dendrimeric face. The smart nanodevice released the encapsulated payload in the presence of H2O2 and glucose, and was successfully evaluated for the enzyme-controlled delivery of the antitumoral drug doxorubicin into HeLa cancer cells.engjournal articlehttps://pubs.rsc.org/en/content/articlelanding/2025/nr/d4nr03740ehttps://www.rsc.org/publishing/journals/nanoscaleopen access53954Física de materialesQuímica22 Física23 Química