León Martínez, RafaelBuendia Abaitua, IzaskunNavarro González De Mesa, ElisaMichalska Dziama, PatrycjaGameiro Ros, IsabelEgea Máiquez, Franisco JavierGarcía Lopez, ManuelaGarcía García, Juan Antonio2024-02-092024-02-092016-04-21León Martínez R, Buendia Abaitua I, Navarro González De Mesa E, Michalska Dziama P, Gameiro Ros I, Egea Máiquez FJ, et al. Compuestos derivados de acrilato de 3-alquilamino-1H-indolilo y su uso en el tratamiento de las enfermeadades neurodegenerativas 2016.https://hdl.handle.net/20.500.14352/100853The invent relates to the methods for producing derivates of 3-alkylamino-1H-indole acrylate(I) with transcription factor Nrf2-inducing activity, free radical scavenging activity and neuroprotective ability. The invention also relates to the use of derivatives according to the invention of treatment of diseases, the pathogenesis of which involves oxidative stress, or diseases involving the deregulationof the activity of phase II genes activated by the factor Nrf2, such as Alzheimer´s disease, Parkinson´s disease, Huntington´s disease, multiple sclerosis, ictus or amyotrophic lateral sclerosis.spapatentWO 2016/059269A1restricted accessCiencias Biomédicas32 Ciencias Médicas