Martínez Alberquilla, IreneGasull, XavierPérez Luna, PatriciaSeco Mera, RubénRuiz Alcocer, JavierCrooke Álvarez, Almudena2023-06-222023-06-222021-12-28Martínez-Alberquilla, I., Gasull, X., Pérez Luna, P. et al. «Neutrophils and Neutrophil Extracellular Trap Components: Emerging Biomarkers and Therapeutic Targets for Age-Related Eye Diseases». Ageing Research Reviews, vol. 74, febrero de 2022, p. 101553. DOI.org (Crossref), https://doi.org/10.1016/j.arr.2021.101553.1568-163710.1016/j.arr.2021.101553https://hdl.handle.net/20.500.14352/72454Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases.In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseasesengAtribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/journal articlehttps://doi.org/10.1016/j.arr.2021.101553https://www.sciencedirect.com/science/article/pii/S1568163721003007?via%3Dihubopen access617.7‑007.681617.7-053.6:612.112.91612.112.91: 616-074NeutrophilNeutrophil extracellular trapDry eyeGlaucomaAge-related macular degenerationDiabetic retinopathyBioquímica (Medicina)OftalmologíaÓptica fisiológica3201.09 Oftalmología