Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease

López Cuenca, InésHoz Montañana, María Rosa DeAlcántara Rey, CeliaGarcía Martín, Elena SalobrarElvira Hurtado, LorenaFernández Albarral, JoséBarabash Bustelo, AnaRamírez Toraño, FedericoDe Frutos Lucas, JaisalmerSalazar Corral, Juan JoséRamírez Sebastián, Ana IsabelRamírez Sebastián, José Manuel2023-06-172023-06-172021-06-02López Cuenca, I., Hoz montañana, M. R., Alcántara Rey, C. et al. «Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Disease». Biomedicines, vol. 9, n.o 6, junio de 2021, p. 638. DOI.org (Crossref), https://doi.org/10.3390/biomedicines9060638.2227-905910.3390/biomedicines9060638https://hdl.handle.net/20.500.14352/8353Received: 6 May 2021 / Accepted: 1 June 2021 / Published: 2 June 2021.A family history (FH+) of Alzheimer’s disease (AD) and ε4 allele of the ApoE gene are the main genetic risk factors for developing AD, whereas ε4 allele plays a protective role in age-related macular degeneration. Ocular vascular changes have been reported in both pathologies. We analyzed the choroidal thickness using optical coherence tomography (OCT) and the foveal avascular zone (FAZ) using OCT-angiography and compared the results with ApoE gene expression, AD FH+, and the presence or absence of hard drusen (HD) in 184 cognitively healthy subjects. Choroidal thickness was statistically significantly different in the (FH−, ε4−, HD+) group compared with (i) both the (FH−, ε4−, HD−) and the (FH+, ε4+, HD+) groups in the superior and inferior points at 1500 µm, and (ii) the (FH+, ε4−, HD+) group in the superior point at 1500 µm. There were statistically significant differences in the superficial FAZ between the (FH+, ε4−, HD+) group and (i) the (FH+, ε4−, HD−) group and (ii) the (FH+, ε4+, HD−) group. In conclusion, ocular vascular changes are not yet evident in participants with a genetic risk of developing AD.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/Foveal Avascular Zone and Choroidal Thickness Are Decreased in Subjects with Hard Drusen and without High Genetic Risk of Developing Alzheimer’s Diseasejournal articlehttps://doi.org/10.3390/biomedicines9060638https://www.mdpi.com/2227-9059/9/6/638open access617.736617.723617.735616.894-053.9Alzheimer’sFamily historyApoE ε4AMDChoroidFoveal avascular zoneHard drusenRetinaOCTOCTANeurociencias (Medicina)Oftalmología2490 Neurociencias3201.09 Oftalmología