Valencia Calvo, MartaDurán Merinero, AlbaLorenzo Aparicio, María Del CarmenGómez Gallego, María Del MarSierra Rodríguez, Miguel ÁngelEguillor, BeatrizEsteruelas Rodrigo, Miguel ÁngelOliván Escó, MontserratOñate, Enrique2024-11-182024-11-182020-01-15Organometallics 2020, 39, 312−3230276-733310.1021/acs.organomet.9b00693https://hdl.handle.net/20.500.14352/110690OsH6(PiPr3)2 has been used to selectively activate C−H, O−H, and C−C sigma bonds in nucleobases and nucleosides, including derivatives of 6-phenylpurine and 4-phenylpyrimidine, leading to cyclometalated mononuclear Os−trihydride complexes, in excellent yields and as single products. Additionally, OsH6(PiPr3)2 promotes the efficient dehydrogenative decarbonylation of primary alcohols in nucleosides having unprotected sugar moieties. The incorporation of OsH2Cl2(PiPr3)2 in the structure of cyclometalated Ir(III) and Rh(III) half-sandwich complexes derived from nucleosides allows the preparation of a class of heterobimetallic bioorganometallic complexes having at least one M−C bond. These methodologies could be used in the future as a way for the orthogonal functionalization of oligonucleotidesengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlepubs.acs.orghttps://pubs.acs.org/doi/10.1021/acs.organomet.9b00693restricted access547Osmium complexesnucleobasessigma bond activationQuímica orgánica (Química)2306 Química Orgánica