Pradillo Orellana, MónicaSantos Coloma, Juan Luis2024-11-212024-11-212018-10Pradillo, M., Santos, J.L. Genes involved in miRNA biogenesis affect meiosis and fertility. Chromosome Res 26, 233–241 (2018). https://doi.org/10.1007/s10577-018-9588-x0967-384910.1007/s10577-018-9588-xhttps://hdl.handle.net/20.500.14352/110930The authors acknowledge the support of the Ministry of Economy and Competitiveness of Spain (by grants AGL2012-38852 and AGL2015-67349-P) and of the European Union (FP7: Meiosys-KBBE-2009-222883).MicroRNAs (miRNAs) are a class of small (containing about 22 nucleotides) single-stranded non-coding RNAs that regulate gene expression at the post-transcriptional level in plants and animals, being absent from unicellular organisms. They act on diverse key physiological and cellular processes, such as development and tissue differentiation, cell identity, cell cycle progression, and programmed cell death. They are also likely to be involved in a broad spectrum of human diseases. Particularly, this review examines and summarizes work characterizing the function of miRNAs in gametogenesis and fertility. Although numerous studies have elucidated the involvement of reproductive-specific small interfering RNAs (siRNAs) in regulating germ cell development and meiosis, less is known about the role of miRNAs in these processes. We focus on the study of hypomorphic and null alleles of genes encoding components of miRNA biogenesis in both plants (Arabidopsis thaliana) and mammals (Mus musculus). We compare the consequences of the presence of these mutations on male meiosis in both species.engjournal article1573-6849https://doi.org/10.1007/s10577-018-9588-xhttps://link.springer.com/journal/10577restricted access577.21575.1581.15ArabidopsisFertilityGametogenesisMeiosisMicemiRNAsBiología molecular (Biología)Genética2415 Biología Molecular2409 Genética