Gómez Mejía, EstherRosales Conrado, NoeliaLeón González, María Eugenia deMadrid Albarrán, María Yolanda2024-01-162024-01-162019Gómez-Mejía E, Rosales-Conrado N, León-González ME, Madrid Y, Determination of phenolic compounds in residual brewing yeastusing matrix solid-phase dispersion extraction assisted by titaniumdioxide nanoparticles 2019, 1601:255-2650021-967310.1016/j.chroma.2019.05.009https://hdl.handle.net/20.500.14352/93305A simple and efficient low-cost matrix solid-phase dispersion (MSPD) extraction based on TiO2nanopar-ticles (NPs) and diatomaceous earth has been developed for the recovery of phenolic compounds fromresidual brewing yeast. Experimental conditions for MSPD extraction were optimized by an experimen-tal design approach. A screening factorial design plus replicates at the center point, followed by surfaceresponse analysis were used. The simultaneous identification and quantification of eleven main nat-ural polyphenols: caffeic, chlorogenic, p-coumaric, 3,4-dihydroxibenzoic, trans-ferulic and gallic acids,kaempferol, myricetin, naringin, quercetin and rutin, was possible by combining MSPD and capillaryliquid chromatography couple to a diode array detection system (cLC-DAD) and liquid chromatogra-phy couple to a triple quadrupole analyzer (LC–MS/MS). Moreover, residual brewing yeast extracts wereevaluated in terms of DPPH (1,1-diphenyl–2 picrylhydrazyl) free radical scavenging activity. Polyphenol-nanoparticle interaction was studied by UV–vis spectroscopy and electron transmission microscopy(TEM), pointing out a stable interplay that assists phenolic isolation. The extracted polyphenol quan-tities were within the 3.2-1,500 g g−1range, and the high antioxidant activity estimated suggested thatdeveloped MSPD is a successful, simple, efficient and rapid method for the extraction and recovery of bioactive phenolic compounds, which promotes the reuse and re-evaluation of brewing yeast agri-foodby-products.engjournal articlehttps://doi.org/10.1016/j.chroma.2019.05.009restricted access543PolyphenolsResidual brewing yeastcLC-DADLC–MS/MSMatrix solid-phase dispersionTitanium dioxide nanoparticlesQuímica analítica (Química)2301 Química Analítica