López García, María EugeniaTurrero Nogués, AgustínCuesta Prieto, PabloLópez Sanz, DavidBruña Fernández, RicardoMarcos Dolado, AlbertoGil Gregorio, PedroYus, MiguelBarabash Bustelo, AnaCabranes Díaz, José AntonioMaestu Unturbe, FernandoFernández Lucas, Alberto Amable2024-02-082024-02-082016López ME, Turrero A, Cuesta P, López-Sanz D, Bruña R, Marcos A, Gil P, Yus M, Barabash A, Cabranes JA, Maestú F, Fernández A. Searching for Primary Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease: A Multivariate Follow-Up Study. J Alzheimers Dis. 2016 Mar 5;52(1):133-43. doi: 10.3233/JAD-1510341387-287710.3233/JAD-151034https://hdl.handle.net/20.500.14352/100161Recent proposals of diagnostic criteria within the healthy aging-Alzheimer’s disease (AD) continuum stressed the role of biomarker information. More importantly, such information might be critical to predict those mild cognitive impairment (MCI) patients at a higher risk of conversion to AD. Usually, follow-up studies utilize a reduced number of potential markers although the conversion phenomenon may be deemed as multifactorial in essence. In addition, not only biological but also cognitive markers may play an important role. Considering this background, we investigated the role of cognitive reserve, cognitive performance in neuropsychological testing, hippocampal volumes, APOE genotype, and magnetoencephalography power sources to predict the conversion to AD in a sample of 33 MCI patients. MCIs were followed up during a 2-year period and divided into two subgroups according to their outcome: The “stable” MCI group (sMCI, 21 subjects) and the “progressive” MCI group (pMCI, 12 subjects). Baseline multifactorial information was submitted to a hierarchical logistic regression analysis to build a predictive model of conversion to AD. Results indicated that the combination of left hippocampal volume, occipital cortex theta power, and clock drawing copy subtest scores predicted conversion to AD with a 100% of sensitivity and 94.7% of specificity. According to these results it might be suggested that anatomical, cognitive, and neurophysiological markers may be considered as “first order” predictors of progression to AD, while APOE or cognitive reserve proxies might play a more secondary role.engAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/journal article1875-8908https://doi.org/10.3233/JAD-15103427060953https://pubmed.ncbi.nlm.nih.gov/27060953/restricted access616.894-053.9Alzheimer’s diseaseAPOECognitive reserveHippocampal volumeMagnetoencephalographyMild cognitive impairmentNeuropsychological testsPredictive modelNeurociencias (Medicina)2490 Neurociencias2402.15 Envejecimiento Somático