An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Arumugam, NatarajanAlmansour, AbdulrahmanKumar, RajuMenéndez Ramos, José CarlosSultan, MujeebKarama, UsamaGhabbour, HazemFun, Hoong-Kun2023-06-182023-06-182015-09-031420-304910.3390/molecules200916142https://hdl.handle.net/20.500.14352/23898A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10-benzylideneanthracen9(10H)-one as a dipolarophile in 1-butyl-3-methylimidazolium bromide([bmim]Br), an ionic liquid. This reaction proceeded regio- and diastereoselectively, in good to excellent yields.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3′]-pyrrolidine and Spiro[oxindole-3,2′-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reactionjournal articlehttps://doi.org/10.3390/molecules200916142https://www.mdpi.com/1420-3049/20/9/16142open access547multicomponent reactions13-dipolar cycloaddition reactionsspirooxindolesspiropyrrolidinesionic liquidsQuímica orgánica (Farmacia)