Paris, Juan L.Torre, Paz de laManzano, MiguelCabañas Criado, María VictoriaFlores, Ana I.Vallet Regí, María Dulce Nombre2023-06-182023-06-182016-03-151742-706110.1016/j.actbio.2016.01.017https://hdl.handle.net/20.500.14352/23180RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCHER ID K-3719-2014 (Miguel Manzano García) ORCID 0000-0001-6238-6111 (Miguel Manzano García) RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado) ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)The potential use of human Decidua-derived mesenchymal stem cells (DMSCs) as a platform to carry mesoporous silica nanoparticles in cancer therapy has been investigated. Two types of nanoparticles were evaluated. The nanoparticles showed negligible toxicity to the cells, a fast uptake and a long retention inside them. Nanoparticle location in the cell was studied by colocalization with the lysosomes. Moreover, the in vitro and in vivo migration of DMSCs towards tumors was not modified by the evaluated nanoparticles. Finally, DMSCs transporting doxorubicin-loaded nanoparticles were capable of inducing cancer cell death in vitro.spajournal articleopen access66546615.46NanoparticlesMesoporous silicaNanomedicineHuman decidua-derived mesenchymal stem cellsMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química Inorgánica