Wu, DanDurán Sampedro, GonzaloFitzgerald, SheilaGarre, MassimilianoO'Shea, Donal2024-01-242024-01-242023Wu, Dan, et al. «Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B–F ree Bioorthogonal Imaging». Chemical Communications, vol. 59, n.o 14, 2023, pp. 1951-54. https://doi.org/10.1039/D2CC06461H.1359-734510.1039/d2cc06461hhttps://hdl.handle.net/20.500.14352/94999Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins.engjournal article1364-548Xhttps://doi.org/10.1039/D2CC06461H.open access54Cyclo additionComplexesBODIPYSuperQuímica23 Química