González-Orús Álvarez-Morujo, RicardoLasso Vázquez, José MaríaGarcía Leal, RobertoScola Yurrita, Barolomé2026-02-052026-02-052014-09González-Orús Álvarez-Morujo R, García Leal R, Lasso Vázquez JM, Scola Yurrita B. Tumor maligno de vaina de nervio periférico afectando al nervio infraorbitario [Malignant peripheral nerve sheath tumour of the infra-orbital nerve]. Neurocirugia (Astur). 2014 Sep-Oct;25(5):240-3. Spanish. doi: 10.1016/j.neucir.2014.02.0021130-147310.1016/j.neucir.2014.02.002https://hdl.handle.net/20.500.14352/131566A malignant peripheral nerve sheath tumour (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. It is even more infrequent for these tumours to affect cranial nerves. We report the case of a 53-year-old man who presented a MPNST involving the infra-orbital nerve, which extended through the orbit and the base of the skull, progressing intracranially. Histological studies identified the tumour as an MPNST. Response to radiotherapy was not complete and radical surgical resection was impossible, so the patient died 10months later. This rare case of MPNST with intracranial involvement illustrates the dismal prognosis for patients with these lesions. Prognosis is poor because of the difficulty of performing radical surgery with free margins in these locations.engjournal articlehttps://doi.org/10.1016/j.neucir.2014.02.00224930860https://www.sciencedirect.com/science/article/abs/pii/S1130147314000669https://pubmed.ncbi.nlm.nih.gov/24930860/restricted access617Cranial nerveInfraorbital nerveMalignant peripheral nerve sheath tumourMalignant schwannomaNervio cranealNervio infraorbitarioNeurosarcomaSchwannoma malignoTumor maligno de vaina de nervio periféricoCirugíaMedicina32 Ciencias Médicas3213 Cirugía