Rojas Lozano, María Del PilarHoz Montañana, María Rosa DeRamírez Sebastián, Ana IsabelFerreras, AntonioGarcía Martín, Elena SalobrarMuñóz Blanco, José LUrcelay Segura, José LuisSalazar Corral, Juan JoséRamírez Sebastián, José Manuel2023-06-162023-06-162019-12Rojas Lozano, P., Hoz Montañana, M. R., Ramírez Sebastián, A. I. et al. «Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study». Brain Sciences, vol. 9, n.o 12, noviembre de 2019, p. 337. DOI.org (Crossref), https://doi.org/10.3390/brainsci9120337.2076-342510.3390/brainsci9120337https://hdl.handle.net/20.500.14352/5973Received: 14 October 2019 / Revised: 12 November 2019 / Accepted: 21 November 2019 / Published: 24 November 2019Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/brainsci9120337https://www.mdpi.com/2076-3425/9/12/337open access616.832.522:611.843617.735-073.75ALSAmyotrophic lateral sclerosisEjeOCTOPtic nerveRetinaNeurociencias (Medicina)Anatomía ocularTécnicas de la imagen2490 Neurociencias