Peláez Prestel, Héctor FernandoSánchez Trincado López, José LuisLafuente Duarte, Esther MaríaReche Gallardo, Pedro Antonio2023-06-162023-06-162021-11-101422-006710.3390/ijms222212149https://hdl.handle.net/20.500.14352/5059The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanisms that enable this tolerance are not yet fully defined. Many works have focused on active immune mechanisms involving dendritic and regulatory T cells. However, epithelial cells also make a major contribution to tolerance by influencing both innate and adaptive immunity. Therefore, the tolerogenic mechanisms concurring in the oral mucosa are intertwined. Here, we review them systematically, paying special attention to the role of oral epithelial cells.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/ijms222212149https://www.mdpi.com/1422-0067/22/22/12149open access612.017OralMucosaToleranceT cellDendritic cellEpithelial cellMedicinaInmunología32 Ciencias Médicas2412 Inmunología