M. Martinez-CengotitabengoaMac-Dowell Mata, Karina SoledadS. AlberichF.J. DiazGarcía Bueno, BorjaR. Rodriguez-JimenezM. BioqueE. BerrocosoM. ParelladaA. LoboP.A. SaizC. MatuteM. BernardoA. Gonzalez-PintoLeza Cerro, Juan Carlos2026-03-242026-03-242015-06-30Martinez-Cengotitabengoa M, MacDowell KS, Alberich S, Diaz FJ, Garcia-Bueno B, Rodriguez-Jimenez R, Bioque M, Berrocoso E, Parellada M, Lobo A, Saiz PA, Matute C, Bernardo M, Gonzalez-Pinto A, Leza JC; FLAMM-PEPs. BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. Schizophr Bull. 2016 Jan;42(1):142-51. doi: 10.1093/schbul/sbv078. Epub 2015 Jun 30. PMID: 26130821; PMCID: PMC4681544.10.1093/schbul/sbv078https://hdl.handle.net/20.500.14352/134267Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1093/schbul/sbv078https://academic.oup.com/schizophreniabulletin/article/42/1/142/2518905?login=trueopen access616.895.8BDNFNGFAntipsychoticFirst-episode psychosisInflammationSchizophreniaCiencias Biomédicas32 Ciencias Médicas