Luna, CarlosAlique, MatildeNavalmoral, EstefaníaNoci, María VictoriaBohórquez Magro, LourdesCarracedo Añón, Julia MaríaRamírez, Rafael2026-02-022026-02-022016-02Luna, C., Alique, M., Navalmoral, E., Noci, M.-V., Bohorquez-Magro, L., Carracedo, J., & Ramírez, R. (2016). Aging-associated oxidized albumin promotes cellular senescence and endothelial damage. Clinical Interventions in Aging, 11, 225-236. https://doi.org/10.2147/CIA.S914531176-909210.2147/cia.s91453https://hdl.handle.net/20.500.14352/131354This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grants (PI11/01536, PI12/01489, PI014/0041 and PI14/00806); Red de Investigación Renal (REDinREN; RD12/0021/002); Comunidad de Madrid (Fibroteam; S2010/BMD-2321); Junta de Andalucía Grants JA0797-2010, P010-CTS-6337, P11-CTS-7352.Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article1178-1998https://doi.org/10.2147/CIA.S91453https://www.dovepress.com/aging-associated-oxidized-albumin-promotes-cellular-senescence-and-end-peer-reviewed-fulltext-article-CIAopen access612.1616.12-005ElderlyOxidative stressMicroparticlesVascular damageFisiologíaCardiologíaSistema cardiovascular3201 Ciencias Clínicas2411 Fisiología Humana3207.04 Patología Cardiovascular