Lorente Méndez, María del CarmenPeña, S.Cerezo, A.2025-11-062025-11-062025Lorente-Méndez, C., Peña, S., & Cerezo, A. (2025). Congenital Non-Epidermolytic Ichthyosis in Two Littermate Mixed-Breed Yorkshire Terriers. Veterinary dermatology, 10.1111/vde.70033. Advance online publication. https://doi.org/10.1111/vde.700330959-449310.1111/vde.70033https://hdl.handle.net/20.500.14352/125842Author Contributions: C. Lorente-Méndez: conceptualization, supervision, and writing. S.Peña: acquisition of data, and writing. A. Cerezo: supervision andwritingCongenital non-epidermolytic ichthyosis was diagnosed in two littermate mixed-breed Yorkshire terrier puppies. Histopathological results confirmed lamellar orthokeratosis; genetic testing for known mutations was negative. Topical treatment improved clinical signs, yet relapse occurred upon discontinuation. This case expands the breeds affected and emphasises the need for life-long management.Se diagnosticó ictiosis congénita no epidermolítica en dos cachorros Yorkshire terrier mestizos de la misma camada. Los resulta- dos histopatológicos confirmaron ortoqueratosis lamelar; las pruebas genéticas para mutaciones conocidas fueron negativas. El tratamiento tópico mejoró los signos clínicos, pero se produjo una recaída al suspenderlo. Este caso amplía el número de razas afectadas y enfatiza la necesidad de un tratamiento de por vida.engjournal article1365-3164https://doi.org/10.1111/vde.7003341117148restricted access636.09Canine ichthyosisCongenital dermatosisGenetic testingHistopathologyKeratoseborrhoeic disorderTopical treatmentVeterinaria3109 Ciencias Veterinarias