Favuzzi, EmiliaMarques Smith, AndréDeogracias, RubénWinterflood, Christian M.Sánchez-Aguilera López, AlbertoMantoan, LauraMaeso, PatriciaFernandes, CathyEwers, HelgeRico, Beatriz2024-01-242024-01-242017-07Emilia Favuzzi, André Marques-Smith, Rubén Deogracias, Christian M Winterflood, Alberto Sánchez-Aguilera, Laura Mantoan, Patricia Maeso, Cathy Fernandes, Helge Ewers, Beatriz Rico. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron . 2017 Aug 2;95(3):639-655.e10. (Epub 2017 Jul 14)10.1016/j.neuron.2017.06.028https://hdl.handle.net/20.500.14352/94949Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron functionengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article0896-6273https://www.sciencedirect.com/science/article/pii/S0896627317305524?via%3Dihub28712654https://pubmed.ncbi.nlm.nih.gov/28712654/open access612AMPA receptorsKv channelsParvalbumin interneuronsActivity-dependentInhibitory circuitriesLearning and memoryPerineuronal netsPlasticitySynapse maturationNeurociencias (Medicina)2490 Neurociencias