Castillo Romero, RafaelHernández-Escobar, DavidGómez Graña, SergioVallet Regí, María Dulce Nombre2023-06-172023-06-172018-03-021521-376510.1002/chem.201706100https://hdl.handle.net/20.500.14352/11979RESEARCHER ID L-2854-2014 (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID G-7562-2016 (Sergio Gómez Graña) ORCID 0000-0002-7736-051X (Sergio Gómez Graña) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)The implementation of nanoparticles as nanomedicines require from sophisticated surface modifications in order to reduce immune response and enhance recognition abilities. In addition to that, Mesoporous Silica nanoparticles present extraordinary host-guest abilities and facile surface functionalization. These two factors make them ideal candidates for the development of novel drug delivery systems, at the expense of increasing the structural complexity. With this idea in mind, a system of triggerable and tunable silica nanoparticles was developed for its application as drug delivery nanocarriers. For that purpose, Diels-Alder cycloaddition adducts were chosen as thermalresponsive units; that permitted to bind Au nanocaps able to block the pores and allow the incorporation of targeting fragments. The capping efficiency was tested under different thermal conditions, obtaining outstanding efficiencies within the physiological range and mild temperatures, as well as enhanced releases under pulsing heating cycles which showed the best release profiles.engjournal articlehttps://www.wiley.com/en-gbhttp://www.ucm.es/valletregigroupopen access66546Mesoporous silicaSilica-Au nanocompositesMesopore reversible gatingDiels-AlderTargetingMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de Materiales