Janssen, JoostReig Ramellat, Rosa MaríaParellada Redondo, María JoséMoreno Ruiz, María del CarmenMoreno Pardillo, Dolores MaríaArango López, CelsoDesco, Manuel2025-01-202025-01-202012-01-18Janssen J, Alemán-Gómez Y, Reig S, Schnack HG, Parellada M, Graell M, Moreno C, Moreno D, Mateos-Pérez JM, Udias JM, Arango C, Desco M. Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis. Br J Psychiatry. 2012 Jan;200(1):30-6. doi: 10.1192/bjp.bp.111.09373210.1192/bjp.bp.111.093732https://hdl.handle.net/20.500.14352/115199Background: Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions. Aims: To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls. Method: Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach. Results: Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar. Conclusions: In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.engjournal articlehttps://doi.org/10.1192/bjp.bp.111.093732https://pubmed.ncbi.nlm.nih.gov/22116979/https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/regional-specificity-of-thalamic-volume-deficits-in-male-adolescents-with-earlyonset-psychosis/9D0401F3640602166EC3EFB296A824FDrestricted access616.895.8early-onset psychosisSchizophreniaPsiquiatría3211 Psiquiatría