Rodríguez-Carreiro, SantiagoMuñoz, EduardoFernández-Ruiz, JavierNavarro González De Mesa, Elisa2024-04-242024-04-242023-08-31Rodríguez-Carreiro, S.; Navarro, E.; Muñoz, E.; Fernández-Ruiz, J. The Cannabigerol Derivative VCE-003.2 Exerts Therapeutic Effects in 6-Hydroxydopamine-Lesioned Mice: Comparison with The Classic Dopaminergic Replacement Therapy. Brain Sci. 2023, 13, 1272. https://doi.org/10.3390/brainsci1309127210.3390/brainsci13091272https://hdl.handle.net/20.500.14352/103460Background: A cannabigerol aminoquinone derivative, so-called VCE-003.2, has been found to behave as a neuroprotective agent (administered both i.p. and orally) in different experimental models of Parkinson’s disease (PD) in mice. These effects were exerted through mechanisms that involved the activation of a regulatory site within the peroxisome proliferator-activated receptor-γ (PPAR-γ). (2) Methods: We are now interested in comparing such neuroprotective potential of VCE-003.2, orally administered, with the effect of the classic dopaminergic replacement therapy with L-DOPA/benserazide in similar conditions, using 6-hydroxydopamine-lesioned mice. (3) Results: The oral administration of VCE-003.2 during 14 days at the dose of 20 mg/kg improved, as expected, the neurological status (measured in motor tests) in these mice. This correlated with a preservation of TH-labelled neurons in the substantia nigra. By contrast, the treatment with L-DOPA/benserazide (during 7 days at 2 mg/kg) was significantly less active in these experimental conditions, in concordance with their profile as a mere symptom-alleviating agent. (4) Conclusions: Our results confirmed again the therapeutic profile of VCE-003.2 in experimental PD and revealed a different and more relevant effect, as a disease modifier, compared to the classic symptom-alleviating L-DOPA treatment. This reinforces the interest in VCE-003.2 for a future clinical development in this disease.engAttribution 4.0 Internationaljournal article10.3390/brainsci13091272https://www.mdpi.com/2076-3425/13/9/1272open access612.015VCE-003.2L-DOPA/benserazideParkinson’s disease6-OHDA-lesioned miceCannabinoids; PPAR-γBioquímica (Medicina)3201.03 Microbiología Clínica