Fernández Lucas, Alberto AmableHornero, RobertoGómez, CarlosTurrero Nogués, AgustínGil Gregorio, PedroMatías Santos, JuanOrtiz, Tomás2023-06-202023-06-202010-04Fernández Lucas, A. A., Hornero, R., Gómez, C. et al. «Complexity Analysis of Spontaneous Brain Activity in Alzheimer Disease and Mild Cognitive Impairment: An MEG Study». Alzheimer Disease & Associated Disorders, vol. 24, n.o 2, abril de 2010, pp. 182-89. DOI.org (Crossref), https://doi.org/10.1097/WAD.0b013e3181c727f7.0893-034110.1097/WAD.0b013e3181c727f7https://hdl.handle.net/20.500.14352/44643Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such “normal” tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia.engjournal articlehttps//doi.org/10.1097/WAD.0b013e3181c727f7http://journals.lww.com/alzheimerjournal/Abstract/2010/04000/Complexity_Analysis_of_Spontaneous_Brain_Activity.12.aspxhttp://www.wolterskluwerhealth.com/restricted access51-76AgingMild cognitive impairmentDementiaComplexityCompensatory mechanismNonlinear analysisAgedAlzheimer diseaseControlled studyFemale humanMagnetoencephalographyMale humanMini mental state examinationNeuropsychological testNonlinear systemPriority journalQualitative analysisRestScoring systemSensitivity and specificityWechsler Memory ScaleWisconsin Card Sorting Test. MeSH: AgedAlzheimer DiseaseBrainCognition DisordersEstadística aplicadaBiología24 Ciencias de la Vida