Aragoneses Cazorla, GuillermoVallet Regí, María Dulce NombreGómez Gómez, M.MilagrosGonzález Ortiz, BlancaLuque García, José Luis2023-06-222023-06-222023-03-13Print: 0026-3672 Electronic: 1436-507310.1007/s00604-023-05712-3https://hdl.handle.net/20.500.14352/73382A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for the antitumor action of a nanosystem based on a Ag core coated with mesoporous silica on which transferrin has been anchored as a targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis has been carried out by gene microarrays and RT-qPCR, while high-resolution mass spectrometry has been used for metabolomics. This multiomics strategy has enabled the discovery of the effect of this nanosystem on different key molecular pathways including the glycolysis, the pentose phosphate pathway, the oxidative phosphorylation and the synthesis of fatty acids, among others.engAtribución 3.0 Españajournal articlehttp://link.springer.com/journal/604open access615.46546MetabolomicsTranscriptomicsMesoporous silica nanoparticlesCancer treatmentElectron transport chain complexATP synthesisMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de Materiales