Puell Marín, María CintaBarrio De Santos, Ana RosaPalomo Álvarez, CatalinaGómez Sanz, Fernando J.Clement Corral, AmayaPérez Carrasco, María Jesús2023-06-202023-06-202012Puell Marín, M. C., Barrio De Santos, A. R., Palomo Álvarez, C. et al. «Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration». Investigative Opthalmology & Visual Science, vol. 53, n.o 11, octubre de 2012, p. 7310. DOI.org (Crossref), https://doi.org/10.1167/iovs.11-8649.0146-040410.1167/iovs.11-8649https://hdl.handle.net/20.500.14352/45208Abierto en la web del editorPurpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD.engAtribución-NoComercial-SinDerivadas 3.0 Españajournal articlehttps//doi.org/10.1167/iovs.11-8649http://iovs.arvojournals.org/article.aspx?articleid=2127992open access617.7617.75Mediated multifocal electroretinogramGeographic AtrphyDark-AdaptationMaculopathyVisionContrastLuminanceChartClassificationDysfunctionOftalmologíaOptometría3201.09 Oftalmología2209.15 Optometría