Hoyos Vidal, María PilarJuanes, OlgaPerona Requena, AlmudenaRumbero, ÁngelHernáiz Gómez-Degano, María Josefa2024-01-302024-01-302021Hoyos P, Perona A, Juanes O, Rumbero Á, Hernáiz MJ. Synthesis of Glycodendrimers with Antiviral and Antibacterial Activity. Chemistry A European J 2021;27:7593–624. https://doi.org/10.1002/chem.202005065.0947-653910.1002/chem.202005065https://hdl.handle.net/20.500.14352/96513Glycodendrimers are an important class of synthetic macromolecules that can be used to mimic many structural and functional features of cell‐surface glycoconjugates. Their carbohydrate moieties perform key important functions in bacterial and viral infections, often regulated by carbohydrate–protein interactions. Several studies have shown that the molecular structure, valency and spatial organisation of carbohydrate epitopes in glycoconjugates are key factors in the specificity and avidity of carbohydrate–protein interactions. Choosing the right glycodendrimers almost always helps to interfere with such interactions and blocks bacterial or viral adhesion and entry into host cells as an effective strategy to inhibit bacterial or viral infections. Herein, the state of the art in the design and synthesis of glycodendrimers employed for the development of anti‐adhesion therapy against bacterial and viral infections is described.engjournal article1521-3765https://doi.org/10.1002/chem.202005065https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202005065restricted access547Anti-infection agentsAntiadhesion therapyCarbohydrate–protein interactionsGlycodendrimersMacromoleculesCienciasQuímicaQuímica orgánica (Química)Ciencias BiomédicasFarmaciaQuímica orgánica (Farmacia)23 Química2306 Química Orgánica2306.06 Química de Los Hidratos de Carbono33 Ciencias Tecnológicas3303 Ingeniería y Tecnología Químicas3303.05 Síntesis Química