Viso Beronda, AlmaFernández de la Pradilla Sainz de Aja, RobertoFlores Aguilar-Amat, Aída2024-02-052024-02-052006-12-11Viso, Alma, et al. «Highly Diastereoselective Staudinger Reaction on 5,6-Dihydropyrazin-2-(1H)-Ones. Synthesis of Enantiopure Fused Oxopiperazino-β-Lactams». Tetrahedron Letters, vol. 47, n.o 50, diciembre de 2006, pp. 8911-15. DOI.org (Crossref), https://doi.org/10.1016/j.tetlet.2006.10.044.10.1016/j.tetlet.2006.10.044https://hdl.handle.net/20.500.14352/99180The highly diastereoselective synthesis of fused oxopiperazino-β-lactams 2 by Staudinger reaction between functionalized ketenes and 5,6-dihydropyrazin-2(1H)-ones 1 has been carried out. Further cleavage of the β-lactam ring produced 2-oxopiperazine-3-acetic acid derivatives 7 with no epimerization and in good yields.engjournal articlehttps://doi.org/10.1016/j.tetlet.2006.10.044restricted accessβ-LactamsPiperazinesAsymmetric synthesisQuímica orgánica (Química)2306 Química Orgánica