Estévez Vázquez, OlgaBenedé Ubieto, RaquelGuo, FeifeiGómez Santos, BeatrizAspichueta, PatriciaReissing, JohannaBruns, TonySanz García, CarlosSydor, SvenjaBechmann, Lars PMaranillo Alcaide, EvaSañudo Tejero, José RamónVázquez Osorio, María TeresaLamas Paz, ArantzaMorán, LauraMazariegos, Marina SCiudin, AndreeaPericàs, Juan M.Peligros Gómez, María IsabelVaquero, JavierMartínez Naves, EduardoLiedtke, ChristianRegueiro González-Barros, José RamónTrautwein, ChristianBañares Cañizares, RafaelCubero Palero, Francisco JavierNevzorova, Yulia2023-06-162023-06-162021-09-22Estévez Vázquez, O., Benedé Ubierto, R., Guo, F. et al. «Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)». Biomedicines, vol. 9, n.o 10, septiembre de 2021, p. 1289. DOI.org (Crossref), https://doi.org/10.3390/biomedicines9101289.10.3390/biomedicines9101289https://hdl.handle.net/20.500.14352/4884Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal article2227-9059https://doi.org/10.3390/biomedicines9101289https://www.mdpi.com/2227-9059/9/10/1289open access616.36616-056.25577.27ObesityMetabolic associated fatty liver disease (MAFLD)SteatohepatitisFibrosisPalmitic acid (PA)Gastroenterología y hepatologíaInmunología3205.03 Gastroenterología2412 Inmunología