Pinilla, DavidMateo Sierra, OlgaGutiérrez, Freddy-AgustinFernández Carballal, CarlosCarrillo Yagüe, Rafael2025-12-162025-12-162005-08Pinilla-Arias D, Mateo-Sierra O, Gutiérrez FA, Fernández-Carballal C, Carrillo R. Immunoterapia en astrocitomas de alto grado: principios y estado actual [Immunotherapy in high grade astrocytomas: principles and current state]. Neurocirugia (Astur). 2005 Aug;16(4):345-58.1130-147310.1016/s1130-1473(05)70401-2https://hdl.handle.net/20.500.14352/129085It is generally accepted that tumour development promotes a systemic response leading to protect the host against cancer. However, tumours may as well elicit a partial immunodeficiency to avoid the development of a complete and active immune response. Since Bloom's first studies on immunotherapy to treat high grade gliomas in 1960, many attempts have been made from different medical specialties to use the immune system as a weapon against a great diversity of cancers. Main objective of this study is to outline the basic features of the immune response inside the Central Nervous System, the strategies employed by astrocytic tumours to evade body defences, and to provide an extended literature review on research on immunotherapy, especially concerning its patho-physiology and the clinical results achieved till date.spajournal articlehttps://doi.org/10.1016/S1130-1473(05)70401-2https://www.sciencedirect.com/science/article/abs/pii/S1130147305704012restricted access615.37InmunoterapiaTratamiento de gliomasCitoquinaLinfocitosCiencias Biomédicas32 Ciencias Médicas