Jiang, LeiWang, MengLi, YouxunZhang, ShuyuanZhu, XiudongZhong, JunjieSun, JintaoTinoco Rivas, MiguelChen, Xiaowei2024-01-232024-01-232023Lei Jiang, Meng Wang, Youxun Li, Shuyuan Zhang, Xiudong Zhu, Junjie Zhong, Jingtao Sun, Miguel Tinoco, and Xiaowei Chen Analytical Chemistry 2023 95 (5), 2884-2892 DOI: 10.1021/acs.analchem.2c044190003-2700https://hdl.handle.net/20.500.14352/94752The frequently mutated phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) gene is associated with multiple tumors and endocytosis of viruses. Identification of muted nucleotides at the hotspot can help in finding the susceptible people who are vulnerable to cancers and viruses. Herein, a simple enzyme-free colorimetric method is developed for the quick detection of PIK3CA gene mutations. The main mechanism lies in the dissimilar interactions between praseodymia nanorods and different nucleotides, as well as the underlying oxidase-mimicking characteristics of praseodymia. With rational designs of probes and processes, this method has great potential for expanded applications in the screening of mutations in other genes of interest.engjournal articlehttps://doi.org/10.1021/acs.analchem.2c04419restricted access543Química analítica (Química)2301 Química Analítica