Benede Ubieto, RaquelEstévez Vázquez, OlgaFlores Perojo, VicenteMacías Rodríguez, Ricardo U.Ruiz Margáin, AstridMartínez Naves, EduardoRegueiro González-Barros, José RamónAvila, Matías A.Trautwein, ChristianBañares Cañizares, RafaelBosch, J.Cubero Palero, Francisco JavierNevzorova, Yulia2023-06-172023-06-172021-03-03Benedé Ubieto, R., Estévez Vázquez, O., Flores Perojo, V. et al. «Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain». Journal of Clinical Medicine, vol. 10, n.o 5, marzo de 2021, p. 1039. DOI.org (Crossref), https://doi.org/10.3390/jcm10051039.10.3390/jcm10051039https://hdl.handle.net/20.500.14352/8508The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Serum levels of Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and AST/ALT ratio were elevated above the Upper Limit of Normal (ULN) in 25.73%, 49.17%, 34.62%, 24.21%, 55.84% and 75% of patients, respectively. Interestingly, significant positive correlation between LDH levels and the AST/ALT ratio with disease outcome was found. Our data showed that SARS-CoV-2 virus infection leads to mild, but significant changes in serum markers of liver injury. The upregulated LDH levels as well as AST/ALT ratios upon admission may be used as additional diagnostic characteristic for COVID-19 patients.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal article2077-0383https://doi.org/10.3390/jcm10051039https://www.mdpi.com/2077-0383/10/5/1039open access578.834:616.98576.3577.2616.36SARS-CoV-2Liver injuryPandemicAST/ALT ratioFerritinGastroenterología y hepatologíaBiología molecular (Biología)Microbiología (Biología)3205.03 Gastroenterología2415 Biología Molecular2414 Microbiología