Nova García, Manuel Joaquín DeGarcía de Sola, RafaelBurgueño Torres, Laura2024-03-192024-03-192024-02-18De Nova-García MJ, Sola RG, Burgueño-Torres L. Analysis of Craniocervical Abnormalities in Osteogenesis Imperfecta during Growth. Applied Sciences. 2024; 14(4):16402076-341710.3390/app14041640https://hdl.handle.net/20.500.14352/102394Osteogenesis Imperfecta (OI) is a genetic disease characterized by osteopenia and bone fragility in which the craniocervical junction is also affected. This is of special relevance due to the high prevalence in anomalies described in the literature as follows: basilar invagination, basilar impression, and platybasia. Methods. We analyzed 19 lateral skull radiographs and 14 magnetic resonance images (MRIs) of 28 patients with OI in which eight linear and five angular measurements were plotted to determine the existence of craniocervical junction anomalies and compare them with 38 lateral skull radiographs and 28 MRIs performed on age-matched healthy controls. Results. From the reference values obtained from the control sample for each age group, we established the limit value at which pathology could be suspected. Some of the variables studied showed a clear trend associated with growth. More than half of the patients (60.71%) presented an anomaly in the skull base. Conclusions. According to the diagnostic criteria used and taking +2.5 SD as the limit value, 10.71% of the patients had basilar invagination, 35.71% had basilar impression, and 39.29% had platybasia, the latter being the most common findingengAttribution 4.0 Internationaljournal articlehttps://www.mdpi.com/2076-3417/14/4/1640open access616.314-053.2615.849616.71572.72Osteogenesis imperfectaCraniocervical junctionPlatybasiaBasilar impressionBasilar invaginationMagnetic resonance imagingCiencias BiomédicasOdontología (Medicina)Odontología infantilDiagnóstico por imagen y medicina nuclear32 Ciencias Médicas3207.14 Osteopatología