Leceta Martínez, JavierKlose, Christoph S. N.Jordan, Stefan2025-06-112025-06-112023-10-09Leceta, J., Klose, C. S. N., & Jordan, S. (2023). Editorial: Community series in immunoregulation at mucosal surfaces volume II. Frontiers in Immunology, 14, 1294936. https://doi.org/10.3389/fimmu.2023.129493610.3389/fimmu.2023.1294936https://hdl.handle.net/20.500.14352/121228The epithelia lining the surfaces in contact with the external environment are represented by the intestinal, respiratory, urinary, and skin epithelia. These locations represent, in surface area and volume, the largest component of the individual’s immune system. They integrate both pathogens and microorganism symbionts with the defense system. In these locations, there are also different cell types, such as epithelial cells, lymphoid cells, and non-lymphoid cells, that carry out the defense mechanisms of both the innate and acquired immune response. The immune response in the mucous membranes also regulates the peripheral immune response. This Research Topic mainly provides articles studying the mechanisms of the innate immune response or its impact on the peripheral immune response.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1664-3224https://doi.org/10.3389/fimmu.2023.1294936open access616-092mucosal immunityinnate immune systemimmunoregulationimmune mechanismanimal modelInmunología3207.10 Inmunopatología