Sánchez Morla, Eva MaríaGarcía‐Jiménez, M.ABarabash Bustelo, AnaMartínez‐Vizcaíno, VicenteMena, JCabranes Díaz, José AntonioBaca‐Baldomero, EnriqueSantos Góez, José Luis2025-01-172025-01-172008Sánchez‐Morla, E. M., et al. «P50 Sensory Gating Deficit Is a Common Marker of Vulnerability to Bipolar Disorder and Schizophrenia». Acta Psychiatrica Scandinavica, vol. 117, n.º 4, abril de 2008, pp. 313-18. DOI.org (Crossref), https://doi.org/10.1111/j.1600-0447.2007.01141.x.0001-690X1600-044710.1111/j.1600-0447.2007.01141.xhttps://hdl.handle.net/20.500.14352/114842Objective: P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gating deficit. Method: P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects. Results: P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (v2 = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables. Conclusion: Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.engjournal articlehttps://doi.org/10.1111/j.1600-0447.2007.01141.xhttps://pubmed.ncbi.nlm.nih.gov/18241306/https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.2007.01141.xrestricted access616.896Bipolar DisorderSchizphreniaSensory GatingCiencias Biomédicas32 Ciencias Médicas