García Martín, Elena SalobrarRojas López, BlancaRamírez Sebastián, Ana IsabelHoz Montañana, Rosa deSalazar Corral, Juan JoséYubero Pancorbo, RaquelGil, PedroTriviño Casado, AlbertoRamirez Sebastian, Jose Manuel2023-06-192023-06-192014-03-181. Hinton DR, Sadun AA, Blanks JC, et al. Optic-nerve degeneration in Alzheimer’s disease. N Engl J Med 1986;315:485–7. 2. He XF, Liu YT, Peng C, et al. Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer’s disease: a meta-analysis. Int J Ophthalmol 2012;5:401–5. 3. Blanks JC, Torigoe Y, Hinton DR, et al. Retinal pathology in Alzheimer’s disease. I. ganglion cell loss in foveal/parafoveal retina. Neurobiol Aging 1996;17:377–84. 4. Tzekov RT, Mullan M. Vision function abnormalities in alzheimer’s disease. Surv Ophthalmol 2013; In press: http://dx.doi.org/10.1016/j.survophthal.2013.10.002. 5. Koronyo Y, Salumbides BC, Black KL, et al. Alzheimer’s disease in the retina: Imaging retinal ab plaques for early diagnosis and therapy assessment. Neurodeg Dis 2012;10:285–93.0161-642010.1016/j.ophtha.2013.12.023https://hdl.handle.net/20.500.14352/35304Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, even before damage to the hippocampal region that affects memory. This fact may reflect retinal neuronal-ganglion cell death and axonal loss in the optic nerve in addition to aging.engAtribución-NoComercial 3.0 Españajournal articlehttp://dx.doi.org/10.1016/j.ophtha.2013.12.023http://www.aaojournal.org/article/S0161-6420(13)01229-3/abstractopen access616.894-053.9617.736Macular thicknessBiomarkersAlzheimer's diseaseNeurociencias (Medicina)OftalmologíaAnatomía ocular2490 Neurociencias3201.09 Oftalmología